John
From your comments below are you suggesting that one should only look
at modulated images?
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Darren Gitelman
2009/5/11 John Ashburner <[log in to unmask]>:
> The result can probably be explained by methodology, but not physiology.
>
> The grey matter volume difference is meaningful, whereas the grey matter
> concentration difference is essentially just showing registration errors.
> The original conception of VBM was to partition the data into "macroscopic"
> differences (encoded by deformations) and "mesoscopic" differences (encoded
> by the residuals). After several heated discussions here in the FIL, the
> perspective changed to one of localising regional volumetric differences.
>
> Best regards,
> -John
>
>> Our group recently submitted VBM paper on sleep disorder.
>> One reviewer impugned the negative result of gray matter volume difference,
>> but the result of gray matter concentration was positive. What is the best
>> way to explain our result in methodology and physiology?Woo-Suk ,
>> TaeChucheon, Korea
>
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