The result can probably be explained by methodology, but not physiology.
The grey matter volume difference is meaningful, whereas the grey matter
concentration difference is essentially just showing registration errors.
The original conception of VBM was to partition the data into "macroscopic"
differences (encoded by deformations) and "mesoscopic" differences (encoded
by the residuals). After several heated discussions here in the FIL, the
perspective changed to one of localising regional volumetric differences.
Best regards,
-John
> Our group recently submitted VBM paper on sleep disorder.
> One reviewer impugned the negative result of gray matter volume difference,
> but the result of gray matter concentration was positive. What is the best
> way to explain our result in methodology and physiology?Woo-Suk ,
> TaeChucheon, Korea
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