I see it quite commonly in anorexic patients with profoundly low BMI. No idea what the cause or significance is, but it seems to respond to refeeding.
Best wishes
Clodagh
-------------------------------
CM Loughrey
Consultant Chemical Pathologist
Belfast City Hospital
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Rafaq Azad
Sent: 16 March 2009 14:44
To: [log in to unmask]
Subject: Re: Significance of low AP
Dear all,
Like Mike, we also don't comment on low ALP (unless it's a paediatric case). Low ALP, <50 iu/L is relatively common, most cases attributed to drugs such as methotrexate and azathiaprine. We have also seen low levels with hypothyroidism. Metal co-factor (magnesium and zinc) deficiency is also a possibility, though we haven't seen any cases in our lab.
Regards,
Rafaq Azad.
>>> "PD Dr. Michael Steiner" <[log in to unmask]>
16/03/2009 14:22 >>>
Dear colleagues,
A lower limit of normal should be provided and adjusted for age (groups).
We usually do not add comments. The story of low AP being typical of
Wilson's disease has been with the clinical community for decades.
However, at least one study refused that claim.
Hereditary hypophosphatasia (rare!) may be another suggestion.
Best regards
Mike
****************************************
PD Dr. med. Michael Steiner
[log in to unmask]
Tel: +49-381-7022701
****************************************
Medizinisches Labor Rostock
Südring 81, D-18059 Rostock
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