Salut Jean,
Would this be helpful?
http://www.cmaj.ca/cgi/content/full/172/5/613-a
Eddy
----- Original Message -----
From: "Jean Levasseur" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Monday, February 16, 2009 10:04 PM
Subject: Survival curve question
>I am trying to interpret the survival curves found in the JUPITER trial
>published in the NEJM last november and I am struggling with the
>interpretation of these curves.
>
> At the start of the trial there were 8901 patients in each group, the
> trial was stopped by the sponsor after 1,9 years for apparent large
> benefit for the treatment group, and there remained less than 200
> subjects at risk at the end of the 5 year follow-up. The hazard ratio is
> calculated at 5 years and shows a large benefit, but less than 2%
> remained at that time...
>
> I am no expert in survival curves, but isn't there something wrong with
> the interpretation ??
>
> Could someone help me with the interpretation of these curves?? and the
> decay of the number at risk and its effect on the interpretation of such
> a survival curve.
>
> The JUPITER trial slides can be found at :
> http://www.brighamandwomens.org/publicaffairs/Images/JUPITER%20Slides%20for%20BWH%20to%20Post%20November%209.pdf
>
> Many thanks !
>
> Jean Levasseur MD, MSc
|