Hi Michael and group
A very important topic Michael. The SORT criteria paper, itself an essential EBM paper for me, (link below) has a list. I hope the formatting isn't distrupted in distribution.
http://www.aafp.org/afp/20040201/548.html
Disease or condition Disease-oriented outcome Patient-oriented outcome
Doxazosin for blood pressure Reduces blood pressure in blacks Increases mortality
Lidocaine for arrhythmia
following acute myocardial
infarction Suppresses arrhythmias Increases mortality
Finasteride for benign
prostatic hypertrophy Improves urinary flow rate No clinically important change in symptom scores
Arthroscopic surgery for
osteoarthritis of the knee Improves appearance of cartilage after débridement No change in function or symptoms at one year
Sleeping infants on their
stomach or side Knowledge of anatomy and physiology
suggests that this will decrease the risk of aspiration Increases risk of sudden infant death syndrome
Vitamin E for heart disease Reduces levels of free radicals No change in mortality
Histamine antagonists and
proton-pump inhibitors for
nonulcer dyspepsia Significantly reduce gastric pH levels Little or no improvement in symptoms in patients with nongastroesophageal reflux disease, nonulcer dyspepsia
Hormone therapy Reduces low-density lipoprotein cholesterol levels,
Increases high-density lipoprotein cholesterol No decrease in cardiovascular or all-cause mortality and an increase in cardiovascular events in women older than 60 years (Women's Health Initiative) with combined hormone therapy
Insulin therapy in type 2 diabetes Keeps blood glucose levels below 120 mg per dL (
6.7 mmol per L) Does not reduce overall mortality
Sodium fluoride for fracture
prevention Increases bone density Does not reduce fracture rate
Lidocaine prophylaxis following
acute myocardial infarction Suppresses arrhythmias Increases mortality
Clofibrate for hyperlipidemia Reduces lipid levels Does not reduce mortality
Beta blockers for heart failure Reduce cardiac output Reduce mortality in moderate to severe disease
Bw
Neal
Neal Maskrey. Director of Evidence Based Therapeutics, National Prescribing Centre, 70 Pembroke Place, Liverpool L69 3GF. Tel: 0151 794 8135. e-mail: [log in to unmask]
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