Hello Greg,
There was a study published in Diabetes Care recently
linking insulin resistance to a statin
http://care.diabetesjournals.org/cgi/content/abstract/31/4/776,
and I am sure there are others
Regards
David Brown
--- Greg Watts <[log in to unmask]> wrote:
> Just a question for the group. Are these insulin
> results just a severe
> case of Insulin Resistance or are they indicative of
> another pathology.
> I am particularly interested in the high level of
> the 1 and 2 hr results
> with a relatively normal GTT.
>
> This is a 52 year old male with mildly raised
> Cholesterol and
> Triglycerides now treated with a Statin. I have
> included the entire
> report, which follows the guidelines outlined by the
> RCPA
> recommendations for insulin resistance diagnosis...
>
------------------------------------------------------------------------
> ---
> Two Hour Glucose Tolerance Test.
> Reference
> Range
> Glucose Fasting 5.5 mmol/L ( 3.9 -
> 5.5 )
> Glucose 1.0 Hour 9.6 mmol/L
> Glucose 2.0 Hour 7.7 mmol/L ( 4.0 -
> 7.7 )
>
> Fasting Urine Glucose NEG
> 2Hrs Post Glucose NEG
>
> Insulin Levels
> Insulin Fasting 1 29.7 mIU/L
> Insulin Fasting 2 32.6 mIU/L
> Insulin Fasting 3 36.5 mIU/L
>
> Mean Fasting Insulin 32.9 mIU/L ( 2.6 - 10
> ) hi
> Insulin - 1Hr 380 mIU/L ( 2.6 - 80
> ) hi
> Insulin - 2Hr 426 mIU/L ( 2.6 - 80
> ) hi
>
> HOMA index 8.0 ( 0.0 -
> 2.0 ) hi
>
>
________________________________________________________________________
> NOTE:
> Mean Fasting Insulin Levels
> 2.6 - 10 Normal
> 10 - 14 Indicate Mild Insulin Resistance
> Over 14 Indicates Moderate to Severe
> Insulin Resistance
> Levels over 20 would be consistent with
> Insulinoma
>
> HOMA Index
> Less than 2.0 Normal
> 2.0 - 2.2 Borderline Resistance
> 2.2 - 3.0 Moderte Resistance
> Greater than 3 Severe Resistance
>
> Insulin Response
>
> An abnormal response in a GTT is a peak insulin
> delayed to 2 Hrs,
> rather
> than one Hr and/or a peak insulin probably above
> 60 and certainly
> above 80 mIU/L.
>
------------------------------------------------------------------------
> -
>
> Thanks for any comments
>
>
> Greg
>
> Greg Watts MSc MA
> Deputy Director
> SYDNEY ADVENTIST HOSPITAL PATHOLOGY
> [log in to unmask]
> _______________________________________
>
> ------ACB discussion List Information--------
> This is an open discussion list for the academic and
> clinical
> community working in clinical biochemistry.
> Please note, archived messages are public and can be
> viewed
> via the internet. Views expressed are those of the
> individual and
> they are responsible for all message content.
> ACB Web Site
> http://www.acb.org.uk
> List Archives
>
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
> List Instructions (How to leave etc.)
> http://www.jiscmail.ac.uk/
>
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|