Yes, I have to confess I do kryptopyrroles every now and then, there
is still quite a demand for the test. It's a modified urine Ehrlich's
test and I can send anyone the protocol if they are interested. We
occasionally get positive results - but not often.
There is actually much word-of-mouth information still to suggest a
correlation between urinary production of kryptopyrroles, zinc and
vitamin B6 deficiency and violent or schizophrenic behaviour. Not a
lot on PubMed etc.
The word kryptopyrrole is the chemical name for
2,4-dimethyl-3-ethylpyrrole, which was originally mis-identified as
the "Mauve factor" and which can be used to standardise the chemical
measurement of urine kryptopyrroles.
The substance actually thought to be excreted in the urine of affected
subjects is hydroxyhaemopyrrolin-2-one, the hydroxy-lactam of
haemopyrrole, which would be a mono-pyrrolle oxidation product of haem
breakdown (I think). So a combination of oxidative stress and
nutritional deficiency gives rise to a substance that affects brain
chemistry and promotes further urinary wasting of nutrients. This
substance is unstable and not commercially available to standardise
HPLC measurement.
I have always been amazed that nobody working in porphyrins seems to
have looked at this one properly.
The name of the scientist currently best known for his work in this
area is Woody R. McGinnis M.D., ([log in to unmask]) who claims to
have positively identified hydroxyhaemopyrrolin-2-one in urine and
published a paper to that effect. In spite of meeting him, I still
came away without a paper or a reference.
So Woody, if you are out there, now is your big chance.
Nick Miller,
London
2008/10/27 Michael McNeely <[log in to unmask]>:
> Try: http://www.doctoryourself.com/hoffer_krypto.html for an interesting
> overview from Dr. Hoffer himself.
>
> Michael McNeely MC FRCPC
> Victoria BC CANADA
>
> -----Original Message-----
> From: Clinical biochemistry discussion list
> [mailto:[log in to unmask]] On Behalf Of Dr. Michael Steiner
> Sent: Monday, October 27, 2008 1:21 PM
> To: [log in to unmask]
> Subject: Kryptopyrrole ...
>
> Dear colleagues,
>
> I was surprised by a request to analyse kryptopyrrole with the aim to
> "assess biochemical imbalances using concepts of orthomolecular medicine".
> Having spent a number of years in laboratory medicine, I have never heard
> before of either krypropyrrole or Mauve factor.
>
> Would any of you please let me know what is being measured ? What kind of
> assay is being employed ? What is the interpretation of the result ?
> Finally, I can not resist asking you about the usefulness of the analysis.
> Any pro and con will be appreciated.
>
> Best regards,
>
> Mike
>
>
> Dr Michael Steiner
> Medizinisches Labor Rostock
> D-18059 Rostock
> GERMANY
>
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