A recent research study showed that excessive fluid intake may be a novel cause of proteinuria (Clark et al, CMAJ 2008; 178:173-5). In this study, of the participants who drank more than 8 large glasses (>2L/d) of fluid, some had both polyuria and proteinuria; some had proteinuria only. When the daily fluid intake was reduced (<2L/d) for one week, the proteinuria and polyuria were largely reversed. To me it seems that proteinuria due to excessive fluid intake is a functional condition, possibly resulted from increased GFR. Does anyone have any suggestions and explanation for this observation?
Thank you,
Liju Yang
Clinical chemist
London Health Sciences Centre
University Hospital
Ontario, Canada
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