This depends of course on your definition of signature motifs, taking this
in a broad sense - many proteins that have multiple functional domains
probably fit the bill, so you could search for "really huge proteins".
For example:
FAS (human, not bacterial) - 2504 amino acids in a single chain (!)
Eukaryotic type II topoisomerases
GYRA/B
LRP1-6
Membrane-spanning phosphatases
...
Artem
-----Original Message-----
From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of DIC
Sent: Friday, January 11, 2008 4:22 AM
To: [log in to unmask]
Subject: [ccp4bb] Multiple Signature Motifs in a single protein
Dear sir,
I'm in something of a fix as I need to compile a
dataset of proteins to test my work. The
dataset would need to consist of proteins that
contain multiple signature motifs. I am having
difficulty finding any with more than two signature
motifs. I would be grateful if you can let me know
of any proteins that have multiple (three or more)
signature motifs.
Thank you in advance.
Yours sincerely,
Bioinformatics Centre
Supercomputer Education and Research Centre
Indian Institute of Science
Bangalore - 560 012
E-mail : [log in to unmask]
Tel : 080-22932469 Ext:28
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