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This depends of course on your definition of signature motifs, taking this in a broad sense - many proteins that have multiple functional domains probably fit the bill, so you could search for "really huge proteins". For example: FAS (human, not bacterial) - 2504 amino acids in a single chain (!) Eukaryotic type II topoisomerases GYRA/B LRP1-6 Membrane-spanning phosphatases ... Artem -----Original Message----- From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of DIC Sent: Friday, January 11, 2008 4:22 AM To: [log in to unmask] Subject: [ccp4bb] Multiple Signature Motifs in a single protein Dear sir, I'm in something of a fix as I need to compile a dataset of proteins to test my work. The dataset would need to consist of proteins that contain multiple signature motifs. I am having difficulty finding any with more than two signature motifs. I would be grateful if you can let me know of any proteins that have multiple (three or more) signature motifs. Thank you in advance. Yours sincerely, Bioinformatics Centre Supercomputer Education and Research Centre Indian Institute of Science Bangalore - 560 012 E-mail : [log in to unmask] Tel : 080-22932469 Ext:28 -- This message has been scanned for viruses and dangerous content by MailScanner, and is believed to be clean. -- This message has been scanned for viruses and dangerous content by MailScanner, and is believed to be clean.