To add my twopence worth, like Pat Kyd we looked at the Diasorin renin
mass kit and decided not to proceed with using it as a routine assay
service.
Reasons:
1. We had to dilute calibrator 1 with the 0 calibrator to generate
a standard that could at least detect the lower end of the 'normal'
range.
And
2. Even so, this did not distinguish the true Conn's syndrome
patients from patients with low but normal renin mass concentrations
I am also interested to note in the data sheet that there is no
imprecsion data on low plasma renin mass concentration, what is the
imprecision with renin mass concentrations of eg 2.0 uiU/ml. I also note
that the lw end of the supine ref range is 2.8 uiU/ml and that further
down the functional sensitivity is quoted as 1.96 uiU/ml. Can the assay
truly differentiate normal low renin from true Conn's syndrome?
Dr Les Perry
Principal Clinical Scientist
Department of Clinical Biochemistry
Barts & The London NHS Trust
Pathology & Pharmacy Building
80 Newark Street
Whitechapel
London E1 2ES
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Mohammed El
Sammak
Sent: 06 November 2007 11:54
To: [log in to unmask]
Subject: Re: Immunoassay for Renin (Mass)
We are using the Diasorin kit on the liaison immunoassay
analyzer since about 6 months.
The assay is givnig good results in the Biorad EQAS.
Attached is the insert sheet for Renin on the Liaison
immunoassay analyzer.
Regards
Mohamed Elsammak
Consultant Chemical Pathologist
King Fahd Specialist Hospital
Dammam
KSA
On Tue, 6 Nov 2007 10:59:43 +0000
Graham handley <[log in to unmask]> wrote:
> Hi
>
> Our Endocrinologist has recently attended a meeting
>where the virtues of
> measuring Renin mass by an immunoassay were extolled.
>
> Does anyone have any information as regards such an
>assay, either as to
> manufacturer of kits or to a Laboratory offering the
>service?
>
> Many thanks
>
> Graham
>
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