Dear colleagues,
Is procalcitonin better than CRP?
Thanks to Joseph and David for these references.
I attach a short summary of these reviews and also include my interpretation of things as they are now.
Best wishes
Ian Barlow
Scunthorpe
UK
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]]On Behalf Of Joseph WATINE
Sent: 20 June 2007 09:19
To: [log in to unmask]
Subject: Re: Procalcitonin
in addition to these 2 articles, at least 5 other systematic reviews or
meta-analysis have been published on the subject. Apparently some of the
conclusions of these 7 articles seem to contradict with each other. Please
feel free to critically summarize these conclusions for us:
1) Gattas DJ, Cook DJ. Procalcitonin as a diagnostic test for sepsis: health
technology assessment in the ICU. J Crit Care. 2003 Mar;18(1):52-8.
2) Sponholz C, Sakr Y, Reinhart K, Brunkhorst F. Diagnostic value and
prognostic implications of serum procalcitonin after cardiac surgery: a
systematic review of the literature. Crit Care. 2006 Oct 13;10(5):R145
3) van Rossum AM, Wulkan RW, Oudesluys-Murphy AM. Procalcitonin as an early
marker of infection in neonates and children. Lancet Infect Dis. 2004
Oct;4(10):620-30.
4) Shafiq N, Malhotra S, Bhasin DK, Rana S, Siddhu S, Pandhi P. Estimating
the diagnostic accuracy of procalcitonin as a marker of the severity of
acute pancreatitis: a meta-analytic approach. JOP. 2005 May 10;6(3):231-7.
5) Jones AE, Fiechtl JF, Brown MD, Ballew JJ, Kline JA. Procalcitonin Test
in the Diagnosis of Bacteremia: A Meta-analysis. Ann Emerg Med. 2006 Dec 8;
[Epub ahead of print]
Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem
Laboratoire de Biologie Polyvalente
Centre Hospitalier Général
12027 Rodez Cedex 9
France
>From: David Gaze <[log in to unmask]>
>Reply-To: David Gaze <[log in to unmask]>
>To: [log in to unmask]
>Subject: Procalcitonin
>Date: Wed, 20 Jun 2007 07:39:19 +0100
>
>
>
>Ian,
>
>
>
>See:
>
>1. Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret G-Y.
>Procalcitonin as a diagnostic test for sepsis in critically ill adults
>and after surgery or trauma: a systematic review and meta-analysis. Crit
>Care Med 2006; 34: 1996-2003
>
>
>
>Regards
>
>
>
>
>
>
>
>David C Gaze
>
>Cardiac Research Scientist
>
>Chemical Pathology
>
>Jenner Wing, Level 2
>
>St George's Healthcare NHS Trust
>
>London, SW17 0QT
>
>Tel: +44 (0)20 8725 5878
>
>Fax: +44 (0)20 8682 0744
>
>Email: [log in to unmask]
><mailto:[log in to unmask]>
>
>P Please consider the environment before printing this e-mail.
>
>-----Original Message-----
>From: Clinical biochemistry discussion list
>[mailto:[log in to unmask]] On Behalf Of Ian Barlow
>Sent: 19 June 2007 17:30
>To: [log in to unmask]
>Subject: Procalcitonin
>
>
>
>Dear colleagues,
>
>I am aware that this topic was discussed about year ago but I wondered
>what the current status was.
>
>Is anyone using this routinely? What platform? What is your experience?
>
>Is anyone aware of any recent systematic reviews or meta analysis?
>I am aware of the one in 2004:-
>Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum
>procalcitonin
>and C-reactive protein levels as markers of bacterial infection: a
>systematic review and meta-analysis. Clin Infect Dis. 2004 Jul
>15;39(2):206-17.
>
>Many thanks
>
>Best wishes
>Ian Barlow
>Scunthorpe
>UK
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