...well perhaps this time it's not just a fiddle factor. Every scatter
diagram I have seen of Mean Blood Glucose vs HbA1c shows a large scatter
around the regression line, so that any particular HbA1c value will be
associated with a range of predicted mean blood glucose values. Last
time I was tinkering with some DCCT data, I calculated that an HbA1c
value of 10% was associated with a MBG of 13.9 mmol/l. The 95%
confidence interval for that estimate was 10.3 to 17.5 mmol/l. It will
be interesting to see if the raw data from the ADAGE trial is similarly
variable.
Peter
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Reynolds Tim
Sent: 12 July 2007 10:17
To: [log in to unmask]
Subject: Re: Goodbye A1c?
As this is just a question of which fiddle factor to apply, we plan to
offer what our clinicians want.
When we went from Gly Hb to DCCT-aligned we gave them both values for 12
months and then dropped GlyHb - we will wait until they tell us what to
do.
TIM
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Prof. Tim Reynolds,
Queen's Hospital,
Belvedere Rd,
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Staffordshire,
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work tel: 01283 511511 ext. 4035
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-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Jonathan G.
Middle
Sent: 12 July 2007 09:39
To: [log in to unmask]
Subject: Re: Goodbye A1c?
No!
The consensus statement has just been emailed to me and I am making this
available to participants. This says that we will all have to triple
report - (1) Correct IFCC Hba1c in the new units, (2) a derived 'DCCT'
number using the NGSP/IFCC master equation and (3) 'APG equivalent'
derived from the yet to be completed international study as long as this
fulfils certain a priori conditions.
Readers of this discussion list will know my views on this- I won't
rehearse them!
regards to all
J
Dr Jonathan Middle
Deputy Director, UK NEQAS Birmingham
0121 414 7300, fax 0121 414 1179
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-----Original Message-----
From: Clinical biochemistry discussion list on behalf of PETER HUDSON
Sent: Thu 12/07/2007 09:21
To: [log in to unmask]
Subject: Goodbye A1c?
Dear all
This article popped up on Medscape yesterday:
http://www.medscape.com/viewarticle/559262?src=mp . It is the proposal
to report HbA1c as an equivalent Mean Blood Glucose. One or two list
members will be aware that I have been grumbling about this for a while.
Does the profession really need yet another derived parameter with a
wide prediction interval?
Peter
Dr. Peter R. Hudson
Principal Biochemist
Maelor Hospital, Wrexham
LL13 7TD
Tel 01978 725867
Fax 01978 366520
P Please consider the environment before printing this email or its
attachment(s)
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