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Ealing Hospital
JOB DESCRIPTION
JOB TITLE: Post-Doctoral
Statistical Genetics Research Fellow
SALARY: £35100 - £38712
DEPARTMENT: Cardiology Dept, Ealing Hospital in
conjunction with Dept of Epidemiology Imperial
College, National Heart and Lung Institute,
Imperial College, and Medical Genetics, Clinical
Pharmacology and Discovery Medicine (CPDM), GSK
ACCOUNTABLE TO: Professors Jaspal S Kooner and Vincent Mooser
Applications are invited for the post of
Post-Doctoral Statistical Genetics Research
Fellow. The appointee will contribute to the
analysis of genome wide association data from the
London Life Sciences Prospective Population
(LOLIPOP) study. The appointee will have
experience in the field of genetic epidemiology,
with a proven track record of publications. The
appointee will be expected to develop a high
quality research programme, under the direction
of the senior LOLIPOP and GSK investigators.
The post will be jointly based in the Department
of Cardiology at Ealing Hospital, and GSK. The
post-holder will collaborate extensively, and
will also hold honorary contracts, with Imperial
College and GSK. The post is funded by an unrestricted grant from GSK.
THE DEPARTMENT
The Department of Cardiology has over twenty
staff involved in research into the genetic and
environmental factors underlying complex diseases
including metaboilic syndrome, hypertension,
diabetes and coronary artery disease in UK Indian
Asians and Northern Europeans. The Department is
led by Professor JS Kooner, who is supported by
three Senior Lecturers (Dr John Chambers, Dr
Stuart Rosen, Dr Ranil De Silva). The Department
works in close collaboration with Imperial
College, and in partnership with Pharmaceutical and biotechnology companies.
The postholder will be based jointly at Ealing
Hospital and GSK, and will also benefit from
close collaboration with the many intellectual
resources of Imperial College, including a wide
range of seminars and lectures, and the advice
and expertise of the National Heart and Lung
Institute, and the Department of Epidemiology and Public Health.
THE PROJECT
Coronary Heart Disease (CHD) mortality is 2-fold
higher in UK Indian Asians than Northern
Europeans, and is not accounted for by recognised
coronary risk factors. The London Life Sciences
Population (LOLIPOP) Research Programme (PIs Prof
JS Kooner, Dr JC Chambers) is an investigation of
30,000 Indian Asians and Europeans. This research
includes a cohort study aimed at identifying
incident coronary heart disease, type-2 diabetes
mellitus, obesity, and chronic kidney disease in
the two populations. To date over 24,000
participants have been recruited and
characterised. Blood samples have been stored and
participants are being followed every 5 years for
cardiovascular and other health events.
Key sub-studies have also been established and include;
i. LOLIPOP Genomics, to identify common genetic
variants underlying susceptibility to complex
traits, including insulin resistance, type-2
diabetes, and atherosclerosis, using whole genome association approaches.
ii. LOLIPOP ‘Omics’, to identify metabolomic,
proteomic and transcriptomic fingerprints linked
with CHD in the two population groups.
iii. LOLIPOP Atherosclerosis, to identify factors
associated with subclinical atherosclerosis, and
its progression, using quantitative markers (EBCT, cIMT).
Genomic, metabolomic and proteomic assays are
being completed as a collaboration between the
LOLIPOP investigators and GSK. 1500 genome wide
association scans have already been completed
using the Affymetrix 500K chip, and a further
1000 scans are expected over the next 6 months.
The results of LOLIPOP and its substudies will
enable identification of factors that contribute
to increased CHD risk amongst Indian Asians, and
help develop effective diagnostic, therapeutic
and preventive strategies for CHD in Indian
Asians that can be readily applied in clinical practice.
DUTIES & RESPONSIBILITIES:
· In collaboration with clinical
researchers, implement a data management system
for genotype and clinical data being collected.
· In collaboration with genomics
researchers, analyse the relationships between
genetic markers and phenotypes (clinical,
metabolomic and proteomic) associated with
atherosclerosis, and other human disease.
· Make a strong contribution to reporting
study results, including writing up for
publication in peer-reviewed journals and
presentations at seminars and conferences
· To plan and carry our research in accordance with the project aims
· To maintain accurate and complete records of all findings
· To present research findings to colleagues and at conferences
· To conduct literature searches and reviews
· To develop contacts and research
collaborations within the Department and wider
academic community in order to further the project aims
· To demonstrate an up to date knowledge
of scientific literature in research area
CONFIDENTIALITY
Information relating to patients, employees and
business of the Trust must be treated in the
strictest confidence. Under no circumstances
should such information be discussed with any
unauthorised person(s) or
organisations. Breaches of confidentiality may lead to disciplinary action.
HEALTH AND SAFETY AT WORK
You are required to take reasonable care of the
health and safety of yourself and other persons
who may be affected by your acts or omissions at
work and to co-operate with the Trust in adhering
to statutory and departmental safety regulations.
EQUAL OPPORTUNITIES
Ealing Hospital NHS Trust stands in opposition to
all forms of less favourable treatment accorded
to employees or job applicants on the grounds of
race, age, sexual orientation, religion,
disability, nationality, martial status, HIV/AIDS
status, trade union membership and/or activity.
RISK MANAGEMENT
You are required to contribute to the control of
risk and use the incident reporting system to
alert the Trust of incidents or near misses that
may compromise the quality of services.
CLINICAL GOVERNANCE
It is the duty of every employee to fulfil their
individual clinical governance responsibilities
and their expected contribution to ensuring that
the Trust complies with benchmarked standards for quality of clinical care.
This list is only an indication of the main tasks
required to be performed. It is not an
exhaustive list of duties and responsibilities
and may be subject to amendments to take account
of changing circumstances. The Trust reserve the
right that you may be required to undertake such
other duties and/or hours of work as may
reasonably be required of you commensurate with
your grade at your normal place of work or from
another location within the Trust.
PERSON SPECIFICATION
Qualifications/Knowledge
Essential:
· a PhD in statistical genetics or genetic
epidemiology or related field (statistics,
epidemiology, population genetics, bioinformatics, mathematics)
Experience
Essential:
· experience of scientific computer programming
· experience of data management and statistical analyses
Desirable:
· experience of designing, and/or
analysing data from, genetic association studies
Skills/Abilities
Essential:
· Ability communicate well in writing,
person to person, and in seminar or conference presentations
· Ability to solve problems using innovative and flexible thinking
· Ability to work autonomously and take responsibility
· Ability to work proactively within an agreed programme
Contact Details
Please send CV and cover letter to:
Professor Jaspal S Kooner MD FRCP
Professor of Clinical Cardiology and Consultant Cardiologist
National Heart & Lung Institute
Imperial College Faculty of Medicine
Hammersmith Hospital Campus
Du Cane Rd,
London
W12 ONN, UK
Tel: +44 20 8383 3037 (PA, Hammersmith)
Fax: +44 20 8967 5884
Mobile: +44 7970 666777
email: <mailto:[log in to unmask]>[log in to unmask]
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James Miller
Department of Statistics
University of Glasgow
15 University Gardens
G12 8QQ
0141 3302474
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