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If interested please respond to the contact details given in the job description and not this email address. Ealing Hospital JOB DESCRIPTION JOB TITLE: Post-Doctoral Statistical Genetics Research Fellow SALARY: £35100 - £38712 DEPARTMENT: Cardiology Dept, Ealing Hospital in conjunction with Dept of Epidemiology Imperial College, National Heart and Lung Institute, Imperial College, and Medical Genetics, Clinical Pharmacology and Discovery Medicine (CPDM), GSK ACCOUNTABLE TO: Professors Jaspal S Kooner and Vincent Mooser Applications are invited for the post of Post-Doctoral Statistical Genetics Research Fellow. The appointee will contribute to the analysis of genome wide association data from the London Life Sciences Prospective Population (LOLIPOP) study. The appointee will have experience in the field of genetic epidemiology, with a proven track record of publications. The appointee will be expected to develop a high quality research programme, under the direction of the senior LOLIPOP and GSK investigators. The post will be jointly based in the Department of Cardiology at Ealing Hospital, and GSK. The post-holder will collaborate extensively, and will also hold honorary contracts, with Imperial College and GSK. The post is funded by an unrestricted grant from GSK. THE DEPARTMENT The Department of Cardiology has over twenty staff involved in research into the genetic and environmental factors underlying complex diseases including metaboilic syndrome, hypertension, diabetes and coronary artery disease in UK Indian Asians and Northern Europeans. The Department is led by Professor JS Kooner, who is supported by three Senior Lecturers (Dr John Chambers, Dr Stuart Rosen, Dr Ranil De Silva). The Department works in close collaboration with Imperial College, and in partnership with Pharmaceutical and biotechnology companies. The postholder will be based jointly at Ealing Hospital and GSK, and will also benefit from close collaboration with the many intellectual resources of Imperial College, including a wide range of seminars and lectures, and the advice and expertise of the National Heart and Lung Institute, and the Department of Epidemiology and Public Health. THE PROJECT Coronary Heart Disease (CHD) mortality is 2-fold higher in UK Indian Asians than Northern Europeans, and is not accounted for by recognised coronary risk factors. The London Life Sciences Population (LOLIPOP) Research Programme (PIs Prof JS Kooner, Dr JC Chambers) is an investigation of 30,000 Indian Asians and Europeans. This research includes a cohort study aimed at identifying incident coronary heart disease, type-2 diabetes mellitus, obesity, and chronic kidney disease in the two populations. To date over 24,000 participants have been recruited and characterised. Blood samples have been stored and participants are being followed every 5 years for cardiovascular and other health events. Key sub-studies have also been established and include; i. LOLIPOP Genomics, to identify common genetic variants underlying susceptibility to complex traits, including insulin resistance, type-2 diabetes, and atherosclerosis, using whole genome association approaches. ii. LOLIPOP ‘Omics’, to identify metabolomic, proteomic and transcriptomic fingerprints linked with CHD in the two population groups. iii. LOLIPOP Atherosclerosis, to identify factors associated with subclinical atherosclerosis, and its progression, using quantitative markers (EBCT, cIMT). Genomic, metabolomic and proteomic assays are being completed as a collaboration between the LOLIPOP investigators and GSK. 1500 genome wide association scans have already been completed using the Affymetrix 500K chip, and a further 1000 scans are expected over the next 6 months. The results of LOLIPOP and its substudies will enable identification of factors that contribute to increased CHD risk amongst Indian Asians, and help develop effective diagnostic, therapeutic and preventive strategies for CHD in Indian Asians that can be readily applied in clinical practice. DUTIES & RESPONSIBILITIES: · In collaboration with clinical researchers, implement a data management system for genotype and clinical data being collected. · In collaboration with genomics researchers, analyse the relationships between genetic markers and phenotypes (clinical, metabolomic and proteomic) associated with atherosclerosis, and other human disease. · Make a strong contribution to reporting study results, including writing up for publication in peer-reviewed journals and presentations at seminars and conferences · To plan and carry our research in accordance with the project aims · To maintain accurate and complete records of all findings · To present research findings to colleagues and at conferences · To conduct literature searches and reviews · To develop contacts and research collaborations within the Department and wider academic community in order to further the project aims · To demonstrate an up to date knowledge of scientific literature in research area CONFIDENTIALITY Information relating to patients, employees and business of the Trust must be treated in the strictest confidence. Under no circumstances should such information be discussed with any unauthorised person(s) or organisations. Breaches of confidentiality may lead to disciplinary action. HEALTH AND SAFETY AT WORK You are required to take reasonable care of the health and safety of yourself and other persons who may be affected by your acts or omissions at work and to co-operate with the Trust in adhering to statutory and departmental safety regulations. EQUAL OPPORTUNITIES Ealing Hospital NHS Trust stands in opposition to all forms of less favourable treatment accorded to employees or job applicants on the grounds of race, age, sexual orientation, religion, disability, nationality, martial status, HIV/AIDS status, trade union membership and/or activity. RISK MANAGEMENT You are required to contribute to the control of risk and use the incident reporting system to alert the Trust of incidents or near misses that may compromise the quality of services. CLINICAL GOVERNANCE It is the duty of every employee to fulfil their individual clinical governance responsibilities and their expected contribution to ensuring that the Trust complies with benchmarked standards for quality of clinical care. This list is only an indication of the main tasks required to be performed. It is not an exhaustive list of duties and responsibilities and may be subject to amendments to take account of changing circumstances. The Trust reserve the right that you may be required to undertake such other duties and/or hours of work as may reasonably be required of you commensurate with your grade at your normal place of work or from another location within the Trust. PERSON SPECIFICATION Qualifications/Knowledge Essential: · a PhD in statistical genetics or genetic epidemiology or related field (statistics, epidemiology, population genetics, bioinformatics, mathematics) Experience Essential: · experience of scientific computer programming · experience of data management and statistical analyses Desirable: · experience of designing, and/or analysing data from, genetic association studies Skills/Abilities Essential: · Ability communicate well in writing, person to person, and in seminar or conference presentations · Ability to solve problems using innovative and flexible thinking · Ability to work autonomously and take responsibility · Ability to work proactively within an agreed programme Contact Details Please send CV and cover letter to: Professor Jaspal S Kooner MD FRCP Professor of Clinical Cardiology and Consultant Cardiologist National Heart & Lung Institute Imperial College Faculty of Medicine Hammersmith Hospital Campus Du Cane Rd, London W12 ONN, UK Tel: +44 20 8383 3037 (PA, Hammersmith) Fax: +44 20 8967 5884 Mobile: +44 7970 666777 email: <mailto:[log in to unmask]>[log in to unmask] ##################################### James Miller Department of Statistics University of Glasgow 15 University Gardens G12 8QQ 0141 3302474 [log in to unmask]