PhD position in analysis of genomic microarray data
The Pulmonary Gene Research is part of the Pneumology department at the
University Hospital Basel, Switzerland. Our research team is
multidisciplinary involving clinicians, molecular biologists,
biostatisticians and bioinformaticians. Our work is focused on the
understanding of lung diseases at the genomic level using microarray
technology. Our current collaborative projects include disease class
prediction in sarcoidosis, biomarker identification in lung cancer and
gene profiling of fibroblasts treated with steroids. Methodological and
analytical aspects of our research are of highest importance. These
include statistical modelling, multivariate data analysis and "omics" data
mining.
We are looking for a highly motivated PhD student with a strong background
in biostatistics. The successful candidate should also have excellent
English oral and written communication skills.
The research of the open position confines all stages of the statistical
analysis of microarray data, e.g. normalization/variance stabilization,
modelling/removal of non-biological variation, identification of
dysregulated genes, model validation, class prediction, etc.
The PhD student will screen the different statistical approaches which
have been developed so far in genomics and in other fields of science
(e.g. chemometrics, environmetrics). A comparative analysis of the most
appropriate techniques will be performed with microarray data.
The candidate will be involved in the development of new statistical
methods and the refinement of existing ones. This project should lead to
the creation of a statistical package including a set of methods for the
analysis of microarray data structures.
Requirements are a Master's diploma in biostatistics or equivalent.
Applicants should have knowledge of multivariate data analysis, and should
be familiar with R/Bioconductor, and other open sources software
solutions. Knowledge of C++ would be advantageous.
Information and application with CV and letter of motivation:
M. Brutsche, MD PhD
Pneumologie Universitätsspital
Petersgraben 4
CH-4031 Basel Switzerland
Tel. +41 61 265 51 95
e-mail: [log in to unmask]
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