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PhD position in analysis of genomic microarray data The Pulmonary Gene Research is part of the Pneumology department at the University Hospital Basel, Switzerland. Our research team is multidisciplinary involving clinicians, molecular biologists, biostatisticians and bioinformaticians. Our work is focused on the understanding of lung diseases at the genomic level using microarray technology. Our current collaborative projects include disease class prediction in sarcoidosis, biomarker identification in lung cancer and gene profiling of fibroblasts treated with steroids. Methodological and analytical aspects of our research are of highest importance. These include statistical modelling, multivariate data analysis and "omics" data mining. We are looking for a highly motivated PhD student with a strong background in biostatistics. The successful candidate should also have excellent English oral and written communication skills. The research of the open position confines all stages of the statistical analysis of microarray data, e.g. normalization/variance stabilization, modelling/removal of non-biological variation, identification of dysregulated genes, model validation, class prediction, etc. The PhD student will screen the different statistical approaches which have been developed so far in genomics and in other fields of science (e.g. chemometrics, environmetrics). A comparative analysis of the most appropriate techniques will be performed with microarray data. The candidate will be involved in the development of new statistical methods and the refinement of existing ones. This project should lead to the creation of a statistical package including a set of methods for the analysis of microarray data structures. Requirements are a Master's diploma in biostatistics or equivalent. Applicants should have knowledge of multivariate data analysis, and should be familiar with R/Bioconductor, and other open sources software solutions. Knowledge of C++ would be advantageous. Information and application with CV and letter of motivation: M. Brutsche, MD PhD Pneumologie Universitätsspital Petersgraben 4 CH-4031 Basel Switzerland Tel. +41 61 265 51 95 e-mail: [log in to unmask]