It is recommended that samples with apparent hyperprolactinemia (>1000
mIU/L) should be screened for Macroprolactin. Some even start with value
>600 mU/L. Also it is very much method dependent. PEG does not work with
AxSYM (bib false positive interference).
Qing Meng
Royal University Hospital
Saskatoon, Canada
>From: "Dr. Michael Steiner" <[log in to unmask]>
>Reply-To: "Dr. Michael Steiner" <[log in to unmask]>
>To: [log in to unmask]
>Subject: Macroprolactin analysis
>Date: Wed, 19 Jul 2006 14:21:22 +0200
>
>Dear list members,
>
>The decision to actively check for macroprolactin depends not only on a
>given value but also on the assay under consideration. Roche's Elecsys
>Prolactin II kit claims that both monoclonal antibodies show a low
>reactivity with most forms of macroprolactin. It is my understanding that
>we need to rule out macroprolactin only in limited cases with very high
>concentrations (> 4000). Moreover, a CE labeled PEG 6000 precipitation
>protocol is provided.
>
>Best regards,
>
>Mike
>
>Dr Michael Steiner
>University of Rostock
>Institute of Clinical Chemistry & Laboratory Medicine
>D-18057 Rostock
>GERMANY
>
>Woodrow Iain wrote:
>
>>Hi list members,
>> We are currently reviewing our practice of performing macroprolactin
>>anlysis by PEG precipitation on all samples with prolactin over the
>>reference range. At what level do other labs perform this?
>> Thanks,
>> Iain Woodrow,
>>Dept of Biochemistry
>>RAEI,
>>Wigan
>
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