Gail wrote
>not really new test
Evaluation of free PSA in screening for Ca prostate was described back in
1995, see:
Bangma CH et al Urology 1995;46:779-784
Catalona WJ et al JAMA 1995;274:1214-1220
There is a good recent paper:
L. Martínez-Piñeiro "Probability of prostate cancer as a function of the
percentage of free prostate-specific antigen in patients with a
non-suspicious rectal examination and total prostate-specific antigen of
4-10 ng/ml" World J Urol 2004;22:124-131
This paper shows ROC curves and tables of sensitivity, specificity, PPV and
NPV. On pages 128 and 129 there are plots of actual original data (total
PSA, Free PSA and % free PSA in Ca and non-Ca cases) by age and by prostate
volume.
Although the 'gold standard' used in the paper was the six-needle biopsy,
The paper notes that 'sextant biopsies are not the optimal way to rule out
prostate cancer, especially in glands over 40 g in which 8-12 cores
significantly increase the cancer detection rate'
This paper is well worth looking at.
Dr R.P.M. Marks
Consultant Chemical Pathologist
Pathology
Calderdale Royal Hospital
Halifax
HX3 0PW
-----Original Message-----
From: Curtis, Gail [mailto:[log in to unmask]]
Sent: 22 January 2005 10:41
To: [log in to unmask]
Subject: Prostate new test - follow-up
Thanks to all who replied.
Consensus suggests complexed PSA (cPSA).
I had checked the 'This Morning' website but the article didn't name the
'protein'. The forwarded Daily Mail link won't open, will try again -
thanks.
I had dismissed cPSA as suspect because I don't regard it as 'new'. Labtests
on-line refers to cPSA in Oct '02 - so not really new test.
Many thanks
Gail Curtis
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