Hi,
It's been a while since I posted this but I just happened to speak to this
patient's physician. Supposedly the wife ( the patient's ) has come to see
the doc and urged him to tell the husband to stop drinking. The doc was
unaware of this...
So the combination of alcohol , Methotrexate, and Lanzoprazole should be
sufficient to explain his GGT.
As for macro forms, we've tried to use PEG precipitation but we get low
recovery for all enzymes ( ALT, AST, ALP, and GGT ) in both our patient and
other samples - 12.5% PEG seems to work for prolactin but not for liver
enzymes.
Wolfgang Schneider
Wolfgang Schneider <[log in to unmask]>@JISCMAIL.AC.UK> on
08/18/2005 03:57:36 PM
Please respond to Wolfgang Schneider <[log in to unmask]>
Sent by: Clinical biochemistry discussion list
<[log in to unmask]>
To: [log in to unmask]
cc:
Subject: Reasons for elevated GGT ?
Hi,
we have a puzzling case of a 58 year old man with psoriatic arthritis who
is being treated with methotrexate, Plaquenil (hydroxychloroquine),
Lanzoprazole, and was just tapered off prednisone. His liver enzymes came
back as:
AST 87 (10-37)
ALT 42 (10-40)
ALP 63 (10-129)
GGT 1084 (11-50)
Both methotrexate and Lanzoprazole are known to increase GGT but to 20x
normal ? He apparently does not drink much alcohol.
Any ideas on how to explain this high level of GGT ?
>>>>>>>>>>>>>>>>>
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