My immediate thought is that the selenium level is not low enough to
cause any serious problems. I can suggest that the selenium will
probably fall in pregnancy due to the increase in plasma volume, which
may be exacerbated by a low selenium intake. Modest supplements would
do no harm, but I would look elsewhere for explanations of the
cardiomyopathy.
Barry
Barry Sampson
Principal Biochemist and Honorary Lecturer
Trace Element Laboratory
Clinical Chemistry
Charing Cross Hospital & Imperial College School of Medicine
London
W6 8RF UK
Phone +44-020-8383 3644
Fax +44-020-8846-7007
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Peter Stromberg
Sent: Wednesday, October 05, 2005 11:23 AM
To: [log in to unmask]
Subject: SELENIUM AND CARDIOMYOPATHY
GR is a 35 year old caucasian lady from Greenock in Scotland who
developed a dilated cardiomyopathy in the mid-trimester of her 4th
pregnancy. She is currently on Levetiracetam and Valproate ( for long
standing epilepsy ), an ACE inhibitor ( Ramipril ), a diuretic (
Frusemide ) and a beta blocker ( carvedilol ).She is not now in failure
but her exercise tolerance is limited. Her serum Selenium was found to
be 0.66 umol/l (0.8 - 2.0 ) which has not yet been checked.Would anyone
like to comment on the significance, if any , of this result.
Kind regards Peter Stromberg
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------ACB discussion List Information--------
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community working in clinical biochemistry.
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