Dear Colleagues,
Regarding Dr Mumtaz' patient with triglycerides of 14000 mg/dL (160
mmol/L), cholesterol of 1190 mg/dL (30 mmol/L) and glucose of 780 mg/dL
(43 mmol/L) we recently managed a patient with triglycerides of 240
mmol/L and in looking found a reference to a patient with a
triglycerides of 270 mmol/L. In our case the samples were cleared with
prolonged centrifugation in a microfuge (approx 10,000 x g) and the
infranate sampled (very carefuly) to make other analyses. it took about
3 hours to get a clear enough infranate. An ultracentrifuge would be
very much quicker!
For anyone interested a poster (including photos!) on this case is
available at the following address (Case Report: Massive
Hypertriglyceridaemia)
http://www.sydpath.stvincents.com.au/other/AACB2003.htm
Regards,
Graham
Graham Jones
Staff Specialist in Chemical Pathology
St Vincent's Hospital, Sydney
Ph: (02) 8382-9160
Fax: (02) 8382-2489
>>> "Dr.Asim Mumtaz" <[log in to unmask]> 11/11/2005 6:13:56 am >>>
We received sample of one month age from paeds ward which was grossly
milky
after centrifugation. The initial tests performed are as follows
pH 7.37
PCO2 19.3
PO2 157.0
Blood Sugar 780 mg/dl
Cholerstrol 1190 mg/dl ( Test performed afte after dilution of 1:10)
Triglycerides 14000 mg/dl
Amylase 45 U/L ( N.V upto 120)
L.F.T could not be performed on autoanalyzer and giving minus
results
Complete Blood Counts not possible due to interference.
Patient preseneted with fever and fits.
No family history of any congenital ailment.
Two other brother and sister normal
We need your opinion for further workup and how to deal with such milky
samples for processing.
What other tests should be carried for having idea of metabolic error
where
we do not have facility of diagnosing inborn error of metabolism.
With regards
Dr.Asim
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