Dear Helen,
I agree with Mohammed that this must be an artefact. Do you know if the
patient had received any doses of cortisol through the line, as some
preparations of this use creatinine as a solubilising agent (this caught us
out once).
Regards,
Graham
At 11:39 AM 29/09/2004 +0100, [log in to unmask] wrote:
>55 yr old female received IV cyclophosphamide and Mesna 996mg in 500 NaCl
>0.9% transfusing @21mls/hr for the previous 48 hours. Double lumen Hickman
>line, at the time of blood sampling Mesna was running through one of the
>lumens, and although pump had been switched off, the line may not have been
>clamped. Serum Creatinine Roche Modular Jaffe based= 614umol/L, confirmed in
>dilution. Normal previous day and repeat sample later in day was 78 umol/L.
>We thought the Mesna caused the elevation, but adding Mesna at varying
>concentration to a pooled serum did not affect the creatinine. She was
>receiving no other IV medication, but was on oral antifungal agents,
>Allopurinol, Losec, Septrin and Ciproxin. I have found references to
>transient creatinine rise with Ciproxin, but above looks more like method
>interference.
>Did someone else report something unusual like this some time back, or any
>other ideas.
>
>____________________________________________________________
>
>Dr. Helen Grimes, Dept. of Clinical Biochemistry, UCH, Galway, Ireland
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