The "disappearance" of HDL along with Apo A1 caused by a Fibrate,
Ciprofibrate, was reported some time ago, . The causality was
demonstrated by the return of HDL and Apo A1 to previous levels
following the reported half-time decay of Ciprofibrate. The Glitazones
were not then involved as the patient was not diabetic and that drug
family was not then commonly available to my knowledge.
This was reported in:
Ciprofibrate and the Lipid Profile. Chandler HA & Batchelor AJ. Lancet
1994; 344(8915), 312-3.
There was at least one other report of this just after in the Annals if
my memory serves me.
A group at the Pasteur Institute at Lille University were investigating
this area but I cannot sat whether they published anything about the
mechanism involved.
--
Dr Henry Chandler
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