Anti GAD antibodies are found in about 70% (higher in children) of newly
diagnosed type 1 diabetics and in nearly 1% of the general population.
Specificity is improved by doing both anti GAD and Anti IA2 (another islet
cell antigen) as only about 0.1% of the general population is positive for
both. (See ref Below)
it may also be used to predict those at risk of developing diabetes which
will be very useful if and when intervention is shown to prevent the
development of diabetes in those at risk.
A serum sample is all that is required.
PS We do it here!
Bingley PJ, Bonifacio E, Williams AJK, et al. Prediction of IDDM in the
general population; strategies based on combinations of autoantibody
markers. Diabetes 1997; 46: 1701-10
68 (2.4%) of 2855 normal school children had GAD alone
60(2.1) had IA2 alone
2(0.1%) had both GAD and IA2
111(83%) of 133 newly diagnosed diabetics aged over 10 had GAD
91 (68%) had IA2
78 (59%) had GAD and IA2
Gerald Maguire
Consultant Clinical Scientist
Department of Clinical Biochemistry and Immunology
Box 232, Addenbrooke's Hospital
Cambridge, CB2 2QR
UK
Tel 01223 217159
Fax 01223 217794
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|