Trevor,
It was not a criticism but an observation I was
making. I believe this was all discussed recently on
this mailbase or on the POCT one. Like the previous
discussion on "rapid estimation of blood alcohol", if
there is a well defined and well documented procedure
and one is able to defend it scientifically when
challenged then well and good.
David Brown
--- Trevor Walmsley <[log in to unmask]>
wrote: > There are many critics of using Clinitest
tablets on
> faecal samples and
> yet there are many labs who still use the test for
> reducing sugars in
> faeces.
>
> The New Zealand packaging of Clinitest states that
> the test is used for
> the determination of urine sugar. The package insert
> says that the test
> is for the quantitation of reducing sugars in urine
> - yet the only
> sugar referred to is glucose. The use of the test
> for faecal samples is
> not mentioned and not excuded in the limitations of
> the test.
>
> Questions (I will collate the replies and post them
> to the group).
>
> 1. Are there any references either validatiing or
> condemning the use of
> Clinitest tablets for the measurement of reducing
> substnaces in faeces?
>
> 2. Do laboratories follw up positive tests by
> carbohydrate
> chromatography as advocated by Richard
> Mainwaring-Burton?
>
> 3. What is are the limitations of the test - flase
> positives - false
> negatives?
>
> 4. Is their external QC available?
>
> 5. How do laborastories apply the test to faeces?
>
> The method we use is to homogenise a faecal sample
> with an two volumes
> of water and perform the test on 15 drops of
> homogenate.
>
> cheers
>
> Trevor Walmsley
>
> >>> "Mainwaring-Burton Richard (RGZ)"
> <[log in to unmask]> 9/6/03 11:02
> pm >>>
> We do a (disputed technique using clinitest) screen
> for reducing
> sugars
> in-house, and then send away positives for proper
> chromatography at a
> centre
> of excellence.
>
> Sugar chromtography is one of the tests which, in my
> view, is sensible
> to
> centralise where one is able to see a significant
> number of positives,
> and
> provide proper advice and follow-up.
>
> with best wishes
>
> Richard
>
> Richard Mainwaring-Burton
> Consultant Biochemist
> Queen Mary's Hospital
> Sidcup, Kent
> DA14 6LT
> 020-8308-3084
>
>
> -----Original Message-----
> From: Paul Masters
> [mailto:[log in to unmask]]
> Sent: 09 June 2003 10:25
> To: [log in to unmask]
> Subject: Stool sugar chromatography
>
>
> We still get a steady trickle of requests for this
> in children with
> diarrhoea, presumably looking for lactase
> deficiency. Both GPs and
> hospital
> paediatricians obviously believe it is a worthwhile
> investigation, but
> is
> it?
> Does anyone know of the evidence to support the use
> of this
> investigation?
> As there is no EQA scheme (or is there?) it is
> difficult to defend its
> use.
> Has anyone dropped it from their repertoire
> recently, and if so what do
> they
> suggest as an alternative when the clinician rings
> up?
>
> Paul
>
> Dr Paul Masters
> Consultant Chemical Pathologist
>
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