Its a great debate into the unknown. I have searched high and low for the
answer to that question and have yet to find a satisfactory response. The
associated question is what the utility of free PSA measurement when the
total PSA is greater than 10 ng/mL.
Let me know what you find out.
David Alter, MD
Clinical/Chemical Pathologist
Spectrum Health
Grand Rapids MI
-----Original Message-----
From: Ian McFarlane [mailto:[log in to unmask]]
Sent: Tuesday, March 18, 2003 12:29 PM
To: [log in to unmask]
Subject: Free/total PSA
Is free/total PSA an independant predictor of prostate malignancy? We had a
57 year old patient with a total PSA of 2.0 and a %free/total ratio of 4%
(RR>17%). Is this %f/t predictive of malignancy even when the total PSA is
in the normal range?
My opinion is that it is. Does anyone have any other views?
Ian Mc
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