I am interested in whether, and how, colleagues report age and sex related adult creatinine ranges. Serum creatinine is higher in men at all ages,
no doubt due to muscle mass. But male creatinine ranges are much more skewed at older ages. My view is to report a different ULN for women
and men, but to use the young adult values for all ages and not to age correct. (ULNs 100 umol/l for women, 120 umol/l for men.) Although it
may be common for the elderly to have higher creatinines ( Whitehead's BUPA tables suggest 183 umol/l as the 97.5%ile for men >72, for
example) it is not desirable as it reflects decreased GFR. My concern is that clinicians would be falsely reassured that renal function was normal
and not modify their prescribing of renally-excreted drugs appropriately. What do other people do: single adult range, sex-related only, or age and
sex-related?
Paul Masters
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