Hello everybody !
To quote from the article in the November 2003 issue of Diabetes Care posted
by Mohammed:
"...
A1C for the diagnosis of diabetes still has disadvantages.
1) A profusion of assay methods has led to different nondiabetic reference
ranges because different glycated hemoglobin fractions have been measured
(30)....
2) A chemical preparation to create uniform calibration standards has only
recently been established (30). This preparation however has not yet been
widely adopted.
3) A1C values may be affected by other conditions (e.g., hemoglobinopathy,
pregnancy, uremia, blood transfusion, and hemolytic anemia), and depending
on the laboratory method used, this may confound the diagnosis of diabetes."
In summary 'HbA1c measurement cannot be used for the diagnosis of diabetes
because of analytical or standardisation problems in the assay'.
Do we agree ?
Dr Robin Marks
Consultant Chemical Pathologist
Calderdale Royal Hospital
Halifax
HX3 0PW
UK
> -----Original Message-----
> From: Mohammad Al-Jubouri [mailto:[log in to unmask]]
> Sent: 28 October 2003 12:03
> To: [log in to unmask]
> Subject: Re: 5.6 mmol/L is new cutoff for IFG
>
>
> Hi Louise
>
> I have attached the relevant article which is freely
> available.
>
> Mohammad
>
>
> --- "Tilbrook Louise (RQ8) Mid Essex Hospital"
> <[log in to unmask]> wrote: > Thank you for
> this information. Do you have the
> > original journal reference
> > to hand?
> >
> > Thanks again
> >
> > Louise Tilbrook
> >
> > Louise Tilbrook
> > Principal Clinical Scientist
> > Department of Clinical Biochemistry
> > Mid Essex Hospital Services NHS Trust
> > Broomfield Hospital
> > Chelmsford
> > Essex
> > CM1 7ET
> >
> > Phone 01245 514013
> > Fax 01245 514077
> >
> >
> >
> > -----Original Message-----
> > From: Mohammad Al-Jubouri
> > [mailto:[log in to unmask]]
> > Sent: 28 October 2003 11:26
> > To: [log in to unmask]
> > Subject: 5.6 mmol/L is new cutoff for IFG
> >
> >
> > An international expert committee on the diagnosis
> > and
> > classification of diabetes mellitus has published
> > revised guidelines, which incorporate new data since
> > the last report of 1997, in the November issue of
> > Diabetes Care. Decreasing the cutoff for impaired
> > fasting glucose from 110 mg/dL to 100 mg/dL could
> > increase diagnoses of prediabetes by approximately
> > 20%.
> > The other diagnostic thresholds remained the same.
> >
> > Mohammad
> >
> >
> > =====
> > Dr. M A Al-Jubouri
> > Consultant Chemical Pathologist
> >
> >
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> =====
> Dr. M A Al-Jubouri
> Consultant Chemical Pathologist
>
> ______________________________________________________________
> __________
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------ACB discussion List Information--------
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community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
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