Dear all
This morning, a patient on Prozac, presented her GP with a sheaf of documents which she has obtained from the internet about the CYP2D6 enzyme. This enzyme is involved in the metabolism of Fluoxetine. Apparently 10% of people have a low activity. Poor metabolism of the drug by an individual has resulted in legal action in the USA. The patient has asked to be tested.
Does anyone do this?
Is it possible to detect CYP2D6 phenotype when the patient is already taking the drug?
The Gp also asks, if an assay is available, should he be testing all his patients on Prozac?
Thanks
Peter Hudson
Peter Hudson
Principal Biochemist
Wrexham Maelor Hospital
Wales, UK. LL13 7TD
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