The BMJ article ignored the fact that the principle problem of statin
therapy is not a 5% decrease in activity when you take the drug at the wrong
time but the 100% decrease in activity when you forget to take the tablet at
all. Most patients seem to remember to take drugs better with their
breakfast than their evening toothpaste so I tell them to take it when they
remember best!
TIM
****************************************************************************
*********
Prof. Tim Reynolds,
Clinical Chemistry Department,
Queens Hospital,
Belvedere Rd.,
Burton-on-Trent,
STAFFORDSHIRE,
DE13 0RB,
UK.
tel: 01283 511511 ext. 4035
fax: 01283 593064
email: [log in to unmask]
alternative email for the all too frequent occasions when the NHS email
connection doesn't work:
[log in to unmask]
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> -----Original Message-----
> From: [log in to unmask] [mailto:[log in to unmask]]
> Sent: 14 October 2003 11:53
> To: [log in to unmask]
> Subject: STATINS AT NIGHT
>
>
> In BMJ 4 Oct 2003 p788 the authors looked at simvastatin and
> showed that
> the cholesterol was higher if the drug was taken in the
> morning. Looking at
> the data reminded me of some calculations I had done a few
> years back for
> my MRCPath looking at what a clinically significant change in
> cholesterol
> was (rather than a statistically significant change). Used CVs for
> analytical and biological variation I think! Anyone else
> looked at this
> article and calculated out what you would expect a clinically
> significant
> change to be?
>
> Thanks
>
> Rob
> Dr Robert Lord
> Department of Clinical Biochemistry
> Rotherham District General Hospital
> Moorgate Road
> Oakwood
> Rotherham
> S60 2UD
>
> Tel 01709 820000
>
> E mail [log in to unmask]
>
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