In BMJ 4 Oct 2003 p788 the authors looked at simvastatin and showed that
the cholesterol was higher if the drug was taken in the morning. Looking at
the data reminded me of some calculations I had done a few years back for
my MRCPath looking at what a clinically significant change in cholesterol
was (rather than a statistically significant change). Used CVs for
analytical and biological variation I think! Anyone else looked at this
article and calculated out what you would expect a clinically significant
change to be?
Thanks
Rob
Dr Robert Lord
Department of Clinical Biochemistry
Rotherham District General Hospital
Moorgate Road
Oakwood
Rotherham
S60 2UD
Tel 01709 820000
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