Dear Cathryn,
Using drugs such as isoniazid and quinine to detect non-compliance was topical in the early 1980s (e.g. Who is taking their tablets? BMJ 1982;285:757-758) but so far as I am aware didn't really take off over here. Similarly I can remember assessing acetylator status using suphasalazine and a simple colourimetric test which again seems to have fallen by the wayside (must admit I'm beginning to feel decidedly middle-aged at this point). A simple colourimetric test for isoniazid in urine (J Clin Pathol 1977;30:84-7) is referenced in a letter published in BMJ 1982;285:1660-1661.
However, I would have thought that our colleagues in microbiology would take a very dim view of us suggesting an antibiotic and an anti-tuberculous one at that, was used as marker for compliance.
Best wishes
Mike
Dr. Mike Bosomworth
Operations Manager for Pathology
Principal Biochemist
Tel. 0113 2064299 Fax 0113 2065971
Mobile 07789 174344
Please visit our web-site at www.leedsteachinghospitals.com
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