Only 5! that is impressive: To get acceptable variation just using total
cholesterol, HDL-cholesterol & blood pressure you need a minimum of 9
repetitions. Add CRP to that cocktail and the number will probebly be 16
[very good for manufacturers].
TIM
****************************************************************************
*********
Prof. Tim Reynolds,
Clinical Chemistry Department,
Queens Hospital,
Belvedere Rd.,
Burton-on-Trent,
STAFFORDSHIRE,
DE13 0RB,
UK.
tel: 01283 511511 ext. 4035
fax: 01283 593064
email: [log in to unmask]
alternative email for the all too frequent occasions when the NHS email
connection doesn't work:
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> -----Original Message-----
> From: Craig Webster [mailto:[log in to unmask]]
> Sent: 20 January 2003 18:29
> To: [log in to unmask]
> Subject: Re: sensitive CRP and CHD
>
>
> Sensitive CRP was mentioned in a Plenary Lecture by Matt
> McQueen at the ICCC
> kyoto. Within individual variation data suggests that up to 5
> measurements
> of sensitive CRP may be neccessary to obtain a value that can
> be used in the
> assessment of CHD risk. WHich is probably even better news for
> manufacturers!
>
> The theory that atherlosclerosis is a chronic low grade inflammatory
> reaction underpins its measurement.
>
> I always thought that CRP was probably under requested in the
> past due to
> long turn around times etc. Now that we can turn the test
> around quickly
> surely we are seeing the benefits of all our execellent work
> on improving
> the service we provide :-)
>
> Craig Webster
> Principal Clinical Biochemist
> Nottingham City Hospital
>
> -----Original Message-----
> From: clinical biochemistry discussion list
> [mailto:[log in to unmask]]On Behalf Of David Brown
> Sent: 20 January 2003 17:25
> To: [log in to unmask]
> Subject: Re: [ACB-CLIN-CHEM-GEN] sensitive CRP and CHD
>
>
> Like everything else, apparently, new "sensitive" CRP
> is the same non specific CRP we have been measuring
> for years, only it is more sensitive in the lower
> range. There is sufficient interest in this assay as a
> cardiac risk factor, that there is more than one assay
> method on the market. My experience of assaying CRP's
> consisted of seeing - most below measurable range -
> and the rest so sky high, that I wondered if the test
> was really necessary (but that was a few years ago).
> Now I may be led to believe that it is as valuable as
> measuring a total cholesterol. There are several major
> studies indicating this. For those who are
> interested,this web page explains sensitive CRP (from
> a manufacturers point of view) and gives some
> references too.
>
> http://www.sonoraquest.com/documents/CardioCRP.pdf
>
>
> Best wishes
>
> David Brown
>
> --- "Mainwaring-Burton Richard (RGZ)"
> <[log in to unmask]>
> wrote: > In the light of the significant numbers of
> raised
> > (non-sensitive) CRPs we
> > report for a plethora of reasons, how do we pick out
> > the significant
> > elevations of sensitive CRP ?
> >
> > Suggested stratigies :
> > 1. do a low sensitivity assay first
> > 2. apologise to potential CHD patients with
> > high CRP - test no good
> > until arthritis/crohns/flu/etc cleared up
> > 3. wait for the cardio-specific version ?
> >
> > With best wishes - happy new year
> > Richard
> > Biochemistry Department
> > Queen Mary's Hospital
> > Sidcup, Kent
> > DA14 6LT
> >
> >
> >
> > -----Original Message-----
> > From: Paul Collinson
> > [mailto:[log in to unmask]]
> > Sent: Tuesday, January 14, 2003 21:07
> > To: [log in to unmask]
> > Subject: Re: sensetive CRP
> >
> >
> > In message <[log in to unmask]>,
> > Dr Clara Henig
> > <[log in to unmask]> writes
> > >Dear all
> > >
> > >What do you know about the utilities of sensitive
> > CRP as a CHD marker?
> > >Does anyone use it routinely? What are your
> > recommendations?
> > >
> > >Thanks
> > >Clara
> > >
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> >
> > There have been a number of publications by Paul
> > Ridker
> >
> > We use it routinely for priomary risk stratification
> > with the cut-off for
> > low
> > risk <1, inetremediate 1-3 and high risk >3 (mg/L)
> >
> > --
> > Paul Collinson
> >
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