Dowart & Chalmers listed 15 different formulas for estimation of the osmolality in their paper in Clin Chem 1975(21;1990-4)....
The theoretical formula (SI-units) has been published as [1,86Na + BUN + glucose]/0,93, (neclecting the minor contributors normally present).(Enger E 1982 Acta Med Scand 212:1-3, Glaser DS 1996 Ann Emerg Med 27)
Whatever formula that might be chosen, the reference range for the gap should be based on the same formula.
Lars Eikvar
MD, PhD
Consultant
Dept. Clin. Chem.
Ullevål University Hospital
N-0407 Oslo
Norway
Phone: +4722119642
Fax: +4722118189
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Fra: David Brown [mailto:[log in to unmask]]
Sendt: 6. juni 2003 12:53
Til: [log in to unmask]
Emne: Use of osmolar gap to "estimate" blood alcohol
I previously asked if there was a standard reference
method for calculating osmolarityand of the 2 who gave
replies (JK --2 X (Na + K) + Gluc +Urea and RGZ--(2 X
Na)+Gluc +Urea) there would be an approximate
difference of at least 2 X K, ie. 8 mmol.
Any more formula users out there?. I used the Sigma
blood alcohol method on our "acute lab analyser" for
many years it was cheap and easy to run.
David Brown
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