Dear Colleagues,
I am writing to seek confirmation and advice from other users of Immulite
assays for PTH measurement.
I note that this may only be relevant to Australian members of the list so
apologies to other countries if you are on different lost numbers of reagents.
We have seen a gradual rise in our internal QC results (from lot numbers
LKPP108 to LKPP113). This has occurred over 8 months and has lead to an
increase of all results by a factor of nearly 2!
Just beween lots LKPP112 and 113 the increase is about 40% and this has
been confirmed by re-running patient samples.
Our response from DPC shows no change in reference interval and indeed
analysis of our running mean (or at least the center of our frequency
histogram for patient results) shows no change between lots 108 and 112. It
must be said that our testing volume is not very large so the accuracy of
this process may not be very good (n=150 - 200).
Has this been seen at other sites and if so to what extent?
Is it related to analyte recovery in serum or plasma matrices?
We are going to factor our results down to match previous results (lot
number 113 to match 112) but this can only be a temporary solution.
Any comments appreciated.
Dr Graham Jones
Staff Specialist in Chemical Pathology
St Vincent's Hospital, Sydney
Ph: (02) 8382-9160
Fax: (02) 8382-2489
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