I have seen two patients (one pregnant, one not) in the last three months
who were admitted with severe pancreatitis and hypertriglyceridaemia in
which alcohol was not implicated as a cause.
WM
At 21:32 03/10/2003 +0100, David Williams wrote:
>I agree that high triglycerides can give rise to necrotising pancreatitis.
>But it is my experience that this is usually associated with high alcohol
>intake.  Alcohol itself has a direct affect on the pancreas; alcohol can
>itself cause hypertriglyceridaemia; and hypertriglyceridaemia can push the
>pancreas already affected by alcohol into the necrotising condition.
>
>We have had several gross hyperlipidaemias over recent years, but as far as
>I am aware the ones that give rise to necrotising pancreatitis have all been
>heavy alcohol drinkers.  Also the time span of the later stages of pregnancy
>is unlikely to be long enough to push the pancreas to necrotisation unless
>it is already harmed by alcohol.
>
>David L. Williams
>
>
>-----Original Message-----
>From: Fleming, Simon - RCHT [mailto:[log in to unmask]]
>Sent: 03 October 2003 21:02
>To: 'David Williams'; [log in to unmask]
>Subject: RE: STATINS AND THIRD TRIMESTER OF PREGNANCY
>
>
>         As far as I am aware there is no necessity to treat FH patients
>during pregnancy, as their cardiovascular risk will not be substantially
>increased for a relatively short period of time compared to a life-time of
>exposure to a high LDL cholesterol.  Triglycerides are however a different
>"kettle of fish" as there is a substantial risk of pregnancy induced
>pancreatitis which can be life-threatening for both mother and unborn child
>
>      Simon Fleming
>         Royal Cornwall Hospital
>
>
>-----Original Message-----
>From: David Williams [mailto:[log in to unmask]]
>Sent: Friday, October 03, 2003 20:57
>To: [log in to unmask]
>Subject: Re: STATINS AND THIRD TRIMESTER OF PREGNANCY
>
>
>We have recently diagnosed gross hyperlipidaemia in a lady approaching
>delivery (total cholesterol 15.6 mmol/L and triglycerides 51.8 mmol/L).
>There were no other predisposing causes (e.g. diabetes, alcoholism
>hypothyroidism, etc).
>
>After delivery (approx 3/52 afterwards) her lipids were again tested - they
>were then virtually normal (chol 5.0 and TGs 2.0).  There is apparently a
>familial condition, hyperlipidaemia of pregnancy, which corrects itself
>after delivery.
>
>We may be doing further tests on this patient - I may pass these on if they
>are of any interest.
>
>David L. Williams
>
>-----Original Message-----
>From: Clinical biochemistry discussion list
>[mailto:[log in to unmask]]On Behalf Of
>[log in to unmask]
>Sent: 03 October 2003 17:56
>To: [log in to unmask]
>Subject: STATINS AND THIRD TRIMESTER OF PREGNANCY
>
>
>Does anyone have experience / data on use of statins in third trimester of
>pregnancy? I realise that they are contraindicated in preg but was
>wondering whether this was related to 1st trimester effects? Am trying
>Questran in this patient at the moment.
>
>Many thanks
>
>Rob
>Dr Robert Lord
>Department of Clinical Biochemistry
>Rotherham District General Hospital
>Moorgate Road
>Oakwood
>Rotherham
>S60 2UD
>
>Tel    01709 820000
>
>E mail [log in to unmask]
>
>________________________________________________________________________
>All email and attachments sent from http://www.Doctors.net.uk have been
>scanned by the MessageLabs SkyScan antivirus system
>________________________________________________________________________
>
>------ACB discussion List Information--------
>This is an open discussion list for the academic and clinical
>community working in clinical biochemistry.
>Please note, archived messages are public and can be viewed
>via the internet. Views expressed are those of the individual and
>they are responsible for all message content.
>
>ACB Web Site
>http://www.acb.org.uk
>List Archives
>http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
>List Instructions (How to leave etc.)
>http://www.jiscmail.ac.uk/
>
>------ACB discussion List Information--------
>This is an open discussion list for the academic and clinical
>community working in clinical biochemistry.
>Please note, archived messages are public and can be viewed
>via the internet. Views expressed are those of the individual and
>they are responsible for all message content.
>
>ACB Web Site
>http://www.acb.org.uk
>List Archives
>http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
>List Instructions (How to leave etc.)
>http://www.jiscmail.ac.uk/
>----------------------------------------------------------------------------
>-------------------------
>The information in this e-mail and any attachments is confidential
>and is intended for the attention and use of the named
>addressee(s).  It must not be disclosed to any other person
>without our authority.  If you are not the intended recipient, or a
>person responsible for delivering it to the intended recipient or
>are aware that this e-mail has been sent to you in error, you are
>not authorised to and must not disclose, copy, distribute, or
>retain this message or any part of it.
>
>We sweep all outgoing messages for the presence of computer
>viruses.  However, we cannot accept any responsibility for any
>loss or damage to your systems due to viruses or malicious code
>not detected.
>
>The statements and opinions expressed in this message are
>those of the author and do not necessarily reflect those of the
>organisations within the Cornwall & Isles of Scilly Health
>Community
>----------------------------------------------------------------------------
>------------------------
>
>------ACB discussion List Information--------
>This is an open discussion list for the academic and clinical
>community working in clinical biochemistry.
>Please note, archived messages are public and can be viewed
>via the internet. Views expressed are those of the individual and
>they are responsible for all message content.
>
>ACB Web Site
>http://www.acb.org.uk
>List Archives
>http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
>List Instructions (How to leave etc.)
>http://www.jiscmail.ac.uk/

From: Dr William J Marshall
Reader and Hon Consultant in Clinical Biochemistry
GKT School of Medicine
London SE5 9PJ
UK

telephone:      020 7346 3275
facsimile:      020 7737 7434
email:  [log in to unmask]

------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.

ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/