It is a very well known phenomena, but work was done on it, see:
Mullen DP: Enzyme studies in pregnancy; in Studies in clinical enzymology, chap. 6, pp. 86-125 (Heinmann, London 1969).
Himaya, A et al: N-acetyl -beta- glucosaminidase and alkaline phosphatase in the sera of pregnant women. An assessment of placental function. Int J Obstet Gynecol 9: 136-140 (1971).
Mark Salkie
"Mascall, Gary (Biochemistry)" wrote:
> We saw a similar picture recently, and on following the patient post partum, saw the Alk. Phos. levels drop back down to normal by around three to four weeks. I discussed it with the Obstetrician who was happy that it was just a case of a "leaky" placenta, he did not feel there was any danger to the foetus, and said that if this does happen it is usually in the later stages of the pregnancy, from around 32 weeks.
>
> I asked him if he had any references, to be told it was common knowledge, so nobody had done too much work on it, and he could not see any reason why, especially as it appears to be an uncommon but harmless presentation.
>
> Regards,
>
> Gary Mascall (Consultant in Clinical Biochemistry)
> Clinical Biochemistry Department
> Kidderminster Hospital
> Worcestershire Acute Hospitals NHS Trust
>
> Tel : 01562 823424 Extn 53465
> email : [log in to unmask]
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> -----Original Message-----
> From: David Burgess [mailto:[log in to unmask]]
> Sent: 25 September 2003 04:26
> To: [log in to unmask]
> Subject: Raised ALP in pregnancy
>
> We have a 28y.o. lady close to term with what appears to be a normal
> pregnancy. Her ALP results are as follows;
> 15/9........... 972 IU/l (N< 117 IU/l adult)
> 13/9.......... 1038
> 12/9.......... 1115
> 11/9.......... 1086
> 10/9.......... 1152
> Her UEC, LFTs and CMP are normal. The isoenzyme analysis suggests a
> placental origin. Has anyone seen this picture? The literature of the
> past ~5 years describes one case with similar results and a benign outcome.
> Regards DB.
>
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