I've just copied that handy reference. This message is just to say it's in the May issue (number 5) not April. Rest of details are correct.
Peadar.
"Annus, Tibor" wrote:
> According to the article in Clin Chem 46 No.4 2000 pg 718-719, Heart-Type Fatty Acid- Binding Protein is not totally heart specific nor does it demonstrate the sensitivity and specificity to detect AMI significantly earlier than do the existing markers.
>
> Tibor Annus
> Chief Scientist
> Biochemistry Dept
> Fremantle Hospital
>
> -----Original Message-----
> From: Chris Budgen [mailto:[log in to unmask]]
> Sent: Wednesday, 10 September 2003 4:24 AM
> To: [log in to unmask]
> Subject: Re: SERUM MYOGLOBIN
>
> Has anyone started using hFABP kits (rennesens make 'em) to screen for
> ACS? heart Fatty Acid Binding Protein is supposedly heart specific and
> starts increasing 15 minutes post cardiac event. rennesens market this
> as a home test screening tool for patients at high risk.
>
> Chris Budgen (Mr)
> POCT Coordinator
> Canterbury Health Laboratories
> Christchurch
> New Zealand
> Internal ext. 81850
> DDI: 03 364 1850
> Cell phone: 025 973 645
> email: [log in to unmask]
> http://www.cdhb.govt.nz/chlabs/Staff2/chrisbudgen.htm
> =============================================
>
> >>> Myers Martin <[log in to unmask]> 10/09/03 01:49:05 >>>
> Thanks to all that replied to my question about the use of serum
> myoglobin
> to rule out ACS.
>
> The background to the question is that our clinicians are keeping low
> risk
> patients in for 12 hours to wait for a cTnT- and then discharging on
> the
> basis of a normal cTnT. The impression is that this uses more bed
> resources
> than before cTnT was introduced. Their question was whether a
> biochemical
> test could be used to rule OUT ACS in low risk patients (based on ECG
> and
> Clinical assessment) and send the patient home earlier than 12 hours.
>
> The replies I received confirmed my view that serum myoglobin does not
> have
> either the sensitivity or specificity to RULE OUT ACS at 6 hours. I
> received one reply where two serial CKMB mass measurements, one on
> admission
> (0 h) and a second 6 h later is being used for ruling out acute MI in
> low
> risk patients. One reply indicated that Cobalt Binding Albumin may be
> a
> future marker to address the early rule out issue.
>
> In practice, from the replies I got, and the lack of suggestion that I
> was
> years out of date!, it appears that a biochemical test to rule out ACS
> and
> send a patient home at 6 hours is not common practice despite this
> being
> suggested in reviews and papers
>
> regards
>
> martin myers
>
> This message and any files transmitted with it are confidential and
> intended
> solely for the individual(s) addressed. If you have received this
> e-mail in
> error, disclosing, copying, distributing or retaining this message or
> any
> part of it is strictly prohibited; please notify the sender immediately
> and
> delete it from your system. Any views or opinions presented are solely
> those
> of the author and do not necessarily represent those of Lancashire
> Teaching
> Hospitals NHS Trust. The Trust accepts no liability for any damage
> caused by
> any virus transmitted with this e-mail, so although virus checked
> before
> transmission, the recipient should also check for the presence of
> viruses.
>
> ------ACB discussion List Information--------
> This is an open discussion list for the academic and clinical
> community working in clinical biochemistry.
> Please note, archived messages are public and can be viewed
> via the internet. Views expressed are those of the individual and
> they are responsible for all message content.
>
> ACB Web Site
> http://www.acb.org.uk
> List Archives
> http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
> List Instructions (How to leave etc.)
> http://www.jiscmail.ac.uk/
>
> **********************************************************************
> ** This email and attachments have been scanned for content and viruses
> and is believed to be clean **
> This email or attachments may contain confidential or legally
> privileged information intended for the sole use of the addressee(s).
> Any use, redistribution, disclosure, or reproduction of this message,
> except as intended, is prohibited. If you received this email in error,
> please notify the sender and remove all copies of the message,
> including any attachments. Any views or opinions expressed in this
> email (unless otherwise stated) may not represent those of Canterbury
> District Health Board
> **********************************************************************
>
> ------ACB discussion List Information--------
> This is an open discussion list for the academic and clinical
> community working in clinical biochemistry.
> Please note, archived messages are public and can be viewed
> via the internet. Views expressed are those of the individual and
> they are responsible for all message content.
>
> ACB Web Site
> http://www.acb.org.uk
> List Archives
> http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
> List Instructions (How to leave etc.)
> http://www.jiscmail.ac.uk/
>
> ------ACB discussion List Information--------
> This is an open discussion list for the academic and clinical
> community working in clinical biochemistry.
> Please note, archived messages are public and can be viewed
> via the internet. Views expressed are those of the individual and
> they are responsible for all message content.
>
> ACB Web Site
> http://www.acb.org.uk
> List Archives
> http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
> List Instructions (How to leave etc.)
> http://www.jiscmail.ac.uk/
--
Dr Peadar McGing,
Principal Biochemist,
Biochemistry Dept, Mater Hospital, Dublin 7, Ireland.
Tel: (+353 1)8032080; Fax: (+353 1)8034781.
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|