I believe that creatinine clearance is never a meaningful measure. I
outlined some of the arguments in 'Creatinine clearance and glomerular
filtration rate' ,Ann Clin Biochem 2000; 37: 98-99.
Brian Payne
Dr. M. Steiner wrote:
>Dear colleagues,
>
>We get (luckily not often) creatinine clearance requests based on very
>low 24 h urine output volumes (e.g. 120 ml/24h). I suggested to refuse
>these requests but team members ask for evidence to do so.
>Would any of you suggest a lower limit of 24 h urinary output below
>which the creatinine clearance becomes a meaningless waste of time (and
>money)? Of course, some reference would nicely backup my suggestion if
>it proves right.
>
>Thank you very much for your input.
>
>Dr. med. Michael Steiner
>University of Rostock
>Institute of Clinical Chemistry & Pathobiochemistry
>D-28057 Rostock
>GERMANY
>
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