HbA1c was checked by HPLC and DCA2000 with excellent
concordance of results. This is a real phenomenon.
thanks
Mohammad
--- "Bakker, A J" <[log in to unmask]> wrote: > It
would be of interest how you measure HbA1c. The
> effect might be different
> in HPLC or immunochemistry methods, so the question
> is if this lowering is
> real or artifical.
>
> To diagnose subclinical haemolysis, you may also
> look at haptoglobin
>
> Andries
>
> Dr. A. J. Bakker, Klinisch chemicus,
> St. Klinisch Chemisch Laboratorium,
> Postbus 850,
> 8901 BR LEEUWARDEN.
> Tel.: 058-2888444
> Fax: 058-2882227
> E-mail: [log in to unmask]
>
>
> > -----Oorspronkelijk bericht-----
> > Van: Mohammad Al-Jubouri
> [SMTP:[log in to unmask]]
> > Verzonden: woensdag 22 oktober 2003 16:31
> > Aan: [log in to unmask]
> > Onderwerp: Dapsone lowering effect on HbA1c
> >
> > Type 2 diabetic had HbA1c of > 7.0%, was started
> on
> > dapsone for dermatitis herpetiformis, his HbA1c
> came
> > down to 3.7% despite documented hyperglycaemia.
> HbA1c
> > is now consistently below 4.0%. His total
> haemoglobin
> > is 12.7 g/dL, retics 2.2% and normal bilirubin.
> Can
> > this be attributed solely to dapsone-induced
> > subclinical haemolysis? Can dapsone interfer
> directly
> > with protein glycation? How to diagnose
> subclinical
> > haemolysis if LDH, Hb, bilirubin and retics are
> all
> > normal, or would this exclude it?
> >
> > thanks
> >
> > Mohammad
> >
> >
> > =====
> > Dr. M A Al-Jubouri
> > Consultant Chemical Pathologist
> >
> >
>
________________________________________________________________________
> > Want to chat instantly with your online friends?
> Get the FREE Yahoo!
> > Messenger http://mail.messenger.yahoo.co.uk
> >
> > ------ACB discussion List Information--------
> > This is an open discussion list for the academic
> and clinical
> > community working in clinical biochemistry.
> > Please note, archived messages are public and can
> be viewed
> > via the internet. Views expressed are those of the
> individual and
> > they are responsible for all message content.
> >
> > ACB Web Site
> > http://www.acb.org.uk
> > List Archives
> >
>
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
> > List Instructions (How to leave etc.)
> > http://www.jiscmail.ac.uk/
=====
Dr. M A Al-Jubouri
Consultant Chemical Pathologist
________________________________________________________________________
Want to chat instantly with your online friends? Get the FREE Yahoo!
Messenger http://mail.messenger.yahoo.co.uk
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|