We have bee looking into the area of screening for anaemia here in Nottingham for the past couple of months. We came to the conclusion that the use of:
FBC, ferritin, B12, folate and CRP would be as good if not better than the introduction of soluble transferrin receptors and zinc protoporphyrin.
I was of the understanding that zinc protoporphyrin was particulary poor in detecting iron deficiancy anaemia and that the literature was split 50/50 on whether it is a good idea or not.
Soluble transferrin receptors appear in principle to be a good idea but the studies have been equivicol in its practical application.
Craig Webster
Nottingham City Hospital
>
> From: "Ballieux, B.E.P.B. (CKCL)" <[log in to unmask]>
> Date: 2003/01/24 Fri AM 10:55:42 GMT
> To: [log in to unmask]
> Subject: Re: [ACB-CLIN-CHEM-GEN] soluble transferrin receptor
>
> Dear Paul,
>
> In stead of sol.Transferrin Receptor you could measure Zinc-Protoporphyrin
> in a hemofluorimeter. It's simple, cheap and fast and provides a excellent
> screening method for iron-deficiency.
> In my previous occupation it was used to screen all samples with MCV < 70
> before further research into hemoglobinopathies was started.
>
> Harthoorn-Lasthuizen EJ, Lindemans J, Langenhuijsen MM. Combined use of
> erythrocyte zinc protoporphyrin and mean corpuscular volume in
> differentiation of thalassemia from iron deficiency anemia. Eur J Haematol
> 1998 Apr;60(4):245-51
>
> Bart Ballieux
> Clinical Biochemist
> Leiden University Medical Centre
> The Netherlands
>
>
> -----Original Message-----
> From: Paul Eldridge [mailto:[log in to unmask]]
> Sent: vrijdag 24 januari 2003 10:24
> To: [log in to unmask]
> Subject: Re: soluble transferrin receptor
>
>
> Colleagues
> I have noticed that this assay is on the menu of our Dade Behring BNII
> nephelometer.
> Does anyone use this method ?
> If so please contact me as I was considering adding it to our menu and
> would welcome the experience of others.
> We are looking at markers for iron deficiency anaemia to aid our
> gastroenterologists to target which patients get on the list for
> gastroscopies.
>
>
> Dr Paul H Eldridge
> Clinical Biochemist
> University Hospital Lewisham
> London SE13 6LH
> UK
> Phone: (44) 020 8333 3255
> Fax: (44) 020 8690 8891
>
>
> [log in to unmask]
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