Dear Michael,
The clinical biochemists' bible (by Tietz) says the following: -
"Aldolase is a ubiquitous enzyme found in skeletal muscle, heart, brain and
kidney. The enzyme is present mainly in the cell sap but also in the
nucleus. The assay of other enzymes, such as AST, LD and CK, generally
provides sufficient diagnostic information; measurement of aldolase is not
recommended."
But there is also a list of many conditions in which serum aldolase levels
are raised and one, hereditary fructose intolerance, in which it is low.
Hope this helps,
Best wishes
David L. Williams
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]]On Behalf Of Dr. M. Steiner
Sent: 18 May 2003 21:44
To: [log in to unmask]
Subject: What is aldolase good for ...
Dear colleagues,
Although decreasing in numbers, we continue to get aldolase requests
mainly from neurologists.
I was wondering if there are clinical conditions necessarily calling for
aldolase activity. What is about its specificity/sensitivity in given
clinical settings?
Any sound review in the current literature or even an evidence-based
approach?
Thank you very much for your input.
Dr. med. Michael Steiner
University of Rostock
Institute of Clinical Chemistry & Pathobiochemistry
D-18057 Rostock
GERMANY
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community working in clinical biochemistry.
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