We investigated somewhat similar infants and found that the conventional
albumin assays (bromcresol green binding) gave falsely elevated results and
the infants had analbuminemia (confirmed genetically). I suggest that you
rely on an immunoassay of serum albumin to obtain an accurate albumin
concentration below 15 g/L. [Influence of methodology on the detection and
diagnosis of congenital analbuminemia. Clin. Chem. 1998; 44: 2365-7].
Edema is characteristically absent or very mild in patients with
analbuminemia or idiopathic hypoalbuminemia.
Tc99-labelled albumin excretion studies are often avialable through
consultation with nuclear medicine colleagues.
Regards, Andrew
Dr. Andrew W. Lyon, Clinical Biochemist / Home Office
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From: Clinical biochemistry discussion list
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Sent: February 13, 2003 5:50 AM
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Subject: LOW ALBUMIN
Would appreciate any advice/thoughts on this one
47 YEAR OLD MALE. Seen in OPD
Albumin consistently < 10 g/l (checked with different assays) for > 1 year.
Other LFT = normal (total protein just below lower end of ref range)
Thanks
Rob
Dr Robert Lord
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