Many thanks for list members who replied. The assay is available at
Freeman, Newcastle (Bob Peaston). Bob has the following advice re this assay
plasma metadrenalines are most useful for their negative predictive values,
very similar to BNP. It should be reserved as a test to exclude phaeo after
all the routine biochemistry testing has been undertaken (urinary cats &
mets etc). If the results are negative but there is still a clinical
suspicion of phaeo, then this is probably when the measurement of free
metadrenalines may be helpful. Unfortunately,although I measure free
metadrenaline levels, values are significantly elevated in patients with
renal impairment. This makes interpretation somewhat difficult with some
patients
There is a paper on the Mayo clinic experience in October issue of JCEM.
Rgds
A
Ahmed Waise
York Hospital
Wigginton Road
YORK YO31 8HE
Tel 01904 725855/ 725670
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