Date sent: Wed, 22 Oct 2003 15:30:44 +0100
Send reply to: Mohammad Al-Jubouri <[log in to unmask]>
From: Mohammad Al-Jubouri <[log in to unmask]>
Subject: Dapsone lowering effect on HbA1c
To: [log in to unmask]
Mohammed,
From my reading of the literature, you don't even have to have
haemolysis - increased red cell turnover is enough to decrease
your A1C. Apparently, about 50% of the A1C is produced in the
last 30 days of the life span of each Hb, so a reduced life span
from the usual 120 days to 90 days would be associated with a
very large decrease in A1C.
Pat
> Type 2 diabetic had HbA1c of > 7.0%, was started on
> dapsone for dermatitis herpetiformis, his HbA1c came
> down to 3.7% despite documented hyperglycaemia. HbA1c
> is now consistently below 4.0%. His total haemoglobin
> is 12.7 g/dL, retics 2.2% and normal bilirubin. Can
> this be attributed solely to dapsone-induced
> subclinical haemolysis? Can dapsone interfer directly
> with protein glycation? How to diagnose subclinical
> haemolysis if LDH, Hb, bilirubin and retics are all
> normal, or would this exclude it?
>
> thanks
>
> Mohammad
>
>
> =====
> Dr. M A Al-Jubouri
> Consultant Chemical Pathologist
>
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