Thanks for Aubrey's and everyone else's comments. The case in question is an
autoimmune polyendocrinopathy type 1 who has been on calcium, thyroxine and
steroids and who is now pregnant with gestational diabetes. In pregnancy the
calcium has been withdrawn as levels have normalised. Could be due to
increases in PTHrP and calcitriol that are reported to occur in pregnancy.
Somewhat off the wall was an idea that PTH processing may be altered in
pregnancy to reduce the amount of PTH 7-84, the fragment that reportedly
opposes the action of PTH 1-84 and which is one of the major fragments
causing the difference in PTH concentration measured in whole and 'intact'
assays. For anyone interested, Bill Fraser's lab in Liverpool measures PTHrP
and both PTH forms (Nichols). I really welcome any more comments, advice etc
about this case.
Anne
Dr Anne Dawnay
Clinical Biochemistry
University College London Hospitals
tel +44 (0)20 7679 9205
fax +44 (0)20 7679 9496
email [log in to unmask]
> Date: Tue, 7 Oct 2003 21:27:43 +0100
> From: ablumsohn <[log in to unmask]>
> Subject: Re: parathyroid hormone
>
> Dear Anne
>
> Scantibodies is not the only company (eg Nichols has an
> assay). However, you need to ask why you would want to
> assay this on a one off sample to send away. In the
> long run PTH assays will shift in this direction, but
> the extra information provided is minimal, and I can't
> think of any circumstances you would want to ship a PTH
> out for this given current evidence.
>
> Aubrey
>
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