> I don't have any experience but wonder whether it is necessary
> to treat hypercholesterolaemia during pregnancy. Cholesterol
> rises during pregnancy but presumably a lot of this goes to the
> foetus and I don't know any evidence that this is particularly
> dangerous for the mother at this time. Are FH mothers
> particularly at risk from cardiovascular problems during
> pregnancy ? We do not treat very young children
> for hypercholesterolaemia for fear of impairing neurodevelopment
> and I wonder if the threat to the mother at this stage from
> hypercholesterolaemia requires potentially causing the opposite
> problem for the foetus.
I have managed a number of women with FH through pregnancy,
discontinuing statin therapy at least one month prior to
conception where possible and not using any lipid lowering
treatment. Cholesterol will certainly rise to very high levels
but I am not aware of any problems associated with this and
certainly the pregnancies I have managed have not been
associated with any unusual difficulty.
Hypertriglyceridaemia is potentially more serious in genetically
predisposed mothers, as there is a definite risk of pancreatitis
and miscarriage.
Best wishes
Ian Young
----------------------
Professor IS Young
Department of Medicine
Wellcome Research Laboratories
Mulhouse Building
Royal Victoria Hospital
Grosvenor Road
Belfast BT12 6BJ
Northern Ireland
tel: +44 2890 632743
fax: +44 2890 235900
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