In message <[log in to unmask]>, [log in to unmask]
writes
>Does anyone have experience / data on use of statins in third trimester of
>pregnancy? I realise that they are contraindicated in preg but was
>wondering whether this was related to 1st trimester effects? Am trying
>Questran in this patient at the moment.
>
>Many thanks
>
I don't have any experience but wonder whether it is necessary to treat
hypercholesterolaemia during pregnancy. Cholesterol rises during
pregnancy but presumably a lot of this goes to the foetus and I don't
know any evidence that this is particularly dangerous for the mother at
this time. Are FH mothers particularly at risk from cardiovascular
problems during pregnancy ? We do not treat very young children for
hypercholesterolaemia for fear of impairing neurodevelopment and I
wonder if the threat to the mother at this stage from
hypercholesterolaemia requires potentially causing the opposite problem
for the foetus.
Any information from anyone as to this clinical conundrum would be
appreciated.
Trevor
--
Trevor Gray
Dept. of Clinical Chemistry,
Northern General Hospital,
Sheffield S5 7AU
0114 271 4309
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