Dear Mohammed,
I see that Donald Young's masterly 2-volume list quotes urine dopamine
excretion at 3 +/- 2 mg/mmol Cr , for patients on Rx with DOPA
(geriatric controls 0.03 +/- 0.02).
He also gives data for several other metabolites.
Best wishes,
Les
> From: Mohammad Al-Jubouri <[log in to unmask]>
> Date: Thu, 4 Sep 2003 16:57:56 +0100 (BST)
> To: Les Culank <[log in to unmask]>
> Subject: Re: Urinary dopamine > 50,000 nmol/24h
>
> Thanks Les
>
> The request came from psychiatry!! so patient must be
> on heavy antipsychotic medication inducing
> parkinsonian like syndome and hence been put on
> sinemet. I have no doubt about metabolism of L-DOPA to
> dopamine which is the pharmacologically active
> metabolite, I am just unfamiliar with this unusually
> high urinary dopamine.
>
> regards
>
> Mohammad
> --- Les Culank <[log in to unmask]> wrote: > Dear
> Mohammed
>>
>> If you gave me 100+ mg of per-oral dopa per day, I
>> would produce a variety
>> of metabolites (I tried it once, some 30+ years ago,
>> with 4 main tlc spots),
>> of which dopamine is one.
>>
>> So 7 or 8 mg per day of urine dopamine sounds
>> feasible for your patient.
>>
>> best wishes
>> Les
>>
>>> From: Mohammad Al-Jubouri <[log in to unmask]>
>>> Reply-To: Mohammad Al-Jubouri
>> <[log in to unmask]>
>>> Date: Thu, 4 Sep 2003 12:08:43 +0100
>>> To: [log in to unmask]
>>> Subject: Urinary dopamine > 50,000 nmol/24h
>>>
>>> Can this be solely due to levodopa that the
>> patient is
>>> taking?
>>>
>>> thanks
>>>
>>> Mohammad
>>>
>>> =====
>>> Dr. M A Al-Jubouri
>>> Consultant Chemical Pathologist
>>>
>>>
>>
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>
> =====
> Dr. M A Al-Jubouri
> Consultant Chemical Pathologist
>
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